Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest
Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest
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Author / Creator
Luo, Yusong , Liu, Ruolan , Zhang, He , Wang, Hongyu , Yin, Hang , Tian, Guopeng , Wang, Bo , Yan, Yunji , Ding, Zilin , Dai, Junqiang , Niu, Liang , Yuan, Guoqiang and Pan, Yawen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Glioma is a common primary nervous system malignant tumor with poor overall cure rate and low survival rate, yet successful treatment still remains a challenge. Here, we demonstrated that amantadine (AMT) exhibits the powerful anti-glioma effect by promoting apoptosis and autophagy in vivo and in vitro. Mechanistically, amantadine induces a large a...
Alternative Titles
Full title
Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_508e436e028f48d5b66b398df7f312f6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_508e436e028f48d5b66b398df7f312f6
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-07228-x
