Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development
Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development
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Publisher
England: The Company of Biologists Ltd
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Language
English
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Publisher
England: The Company of Biologists Ltd
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Contents
Cancer cells hijack developmental growth mechanisms but whether tissue morphogenesis and architecture modify tumorigenesis is unknown. Here, we characterized a new mouse model of sporadic thyroid carcinogenesis based on inducible expression of BRAF carrying a Val600 Glu (V600E) point mutation (BRAFV600E) from the thyroglobulin promoter (TgCreERT2)....
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Full title
Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development
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TN_cdi_doaj_primary_oai_doaj_org_article_508f6d6970624701985ec7553bd80cdf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_508f6d6970624701985ec7553bd80cdf
Other Identifiers
ISSN
1754-8403,1754-8411
E-ISSN
1754-8411
DOI
10.1242/dmm.048887
