CRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements
CRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Pre-mRNA splicing, a key process in gene expression, can be therapeutically modulated using various drug modalities, including antisense oligonucleotides (ASOs). However, determining promising targets is hampered by the challenge of systematically mapping splicing-regulatory elements (SREs) in their native sequence context. Here, we use the catalyt...
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CRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements
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TN_cdi_doaj_primary_oai_doaj_org_article_50eafa1abd784c8ab1e55ddaab52c2b2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_50eafa1abd784c8ab1e55ddaab52c2b2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-47140-8
