ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL
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Full title
Author / Creator
Wutz, Gordana , Ladurner, Rene , St Hilaire, Brian Glenn , Stocsits, Roman R , Nagasaka, Kota , Pignard, Benoit , Sanborn, Adrian , Tang, Wen , Várnai, Csilla , Ivanov, Miroslav P , Schoenfelder, Stefan , van der Lelij, Petra , Huang, Xingfan , Dürnberger, Gerhard , Roitinger, Elisabeth , Mechtler, Karl , Davidson, Iain Finley , Fraser, Peter , Lieberman-Aiden, Erez and Peters, Jan-Michael
Publisher
Cambridge: eLife Sciences Publications Ltd
Journal title
Language
English
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Publisher
Cambridge: eLife Sciences Publications Ltd
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Contents
Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL. Although WAPL limits cohesin’s chromatin residence time to minutes, it has been reported that some loops exist for hours. How these loops can...
Alternative Titles
Full title
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL
Authors, Artists and Contributors
Author / Creator
Ladurner, Rene
St Hilaire, Brian Glenn
Stocsits, Roman R
Nagasaka, Kota
Pignard, Benoit
Sanborn, Adrian
Tang, Wen
Várnai, Csilla
Ivanov, Miroslav P
Schoenfelder, Stefan
van der Lelij, Petra
Huang, Xingfan
Dürnberger, Gerhard
Roitinger, Elisabeth
Mechtler, Karl
Davidson, Iain Finley
Fraser, Peter
Lieberman-Aiden, Erez
Peters, Jan-Michael
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_50f9b518193c4de2ba8e04afd984547d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_50f9b518193c4de2ba8e04afd984547d
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.52091
