Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glyco...
Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Mucinases of human gut bacteria cleave peptide bonds in mucins strictly depending on the presence of neighboring
O
-glycans. The
Akkermansia muciniphila
AM0627 mucinase cleaves specifically in between contiguous (bis)
O
-glycans of defined truncated structures, suggesting that this enzyme may recognize clustered
O
-glycan pa...
Alternative Titles
Full title
Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut
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TN_cdi_doaj_primary_oai_doaj_org_article_51738a196d424c47bf488285e9c058f0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_51738a196d424c47bf488285e9c058f0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32021-9
