Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk he...
Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma
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Full title
Author / Creator
Fang, Jie , Singh, Shivendra , Cheng, Changde , Natarajan, Sivaraman , Sheppard, Heather , Abu-Zaid, Ahmed , Durbin, Adam D. , Lee, Ha Won , Wu, Qiong , Steele, Jacob , Connelly, Jon P. , Jin, Hongjian , Chen, Wenan , Fan, Yiping , Pruett-Miller, Shondra M. , Rehg, Jerold E. , Koo, Selene C. , Santiago, Teresa , Emmons, Joseph , Cairo, Stefano , Wang, Ruoning , Glazer, Evan S. , Murphy, Andrew J. , Chen, Taosheng , Davidoff, Andrew M. , Armengol, Carolina , Easton, John , Chen, Xiang and Yang, Jun
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. Here, we report an improved MYC-driven hepatoblastoma-like murine model that recapitulates the pathological features of embryonal type of hepatoblastoma, with transcriptomics resembling th...
Alternative Titles
Full title
Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma
Authors, Artists and Contributors
Author / Creator
Singh, Shivendra
Cheng, Changde
Natarajan, Sivaraman
Sheppard, Heather
Abu-Zaid, Ahmed
Durbin, Adam D.
Lee, Ha Won
Wu, Qiong
Steele, Jacob
Connelly, Jon P.
Jin, Hongjian
Chen, Wenan
Fan, Yiping
Pruett-Miller, Shondra M.
Rehg, Jerold E.
Koo, Selene C.
Santiago, Teresa
Emmons, Joseph
Cairo, Stefano
Wang, Ruoning
Glazer, Evan S.
Murphy, Andrew J.
Chen, Taosheng
Davidoff, Andrew M.
Armengol, Carolina
Easton, John
Chen, Xiang
Yang, Jun
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_518df2bf603d4dbaa5922a65b63e4a51
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_518df2bf603d4dbaa5922a65b63e4a51
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39717-6
