Including random centre effects in design, analysis and presentation of multi-centre trials
Including random centre effects in design, analysis and presentation of multi-centre trials
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London: BioMed Central Ltd
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English
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London: BioMed Central Ltd
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Background In large multicentre trials in diverse settings, there is uncertainty about the need to adjust for centre variation in design and analysis. A key distinction is the difference between variation in outcome (independent of treatment) and variation in treatment effect. Through re-analysis of the CRASH-2 trial (2010), this study clarifies wh...
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Including random centre effects in design, analysis and presentation of multi-centre trials
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TN_cdi_doaj_primary_oai_doaj_org_article_5201f71bee4c446d9f92357a2bd1e48d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5201f71bee4c446d9f92357a2bd1e48d
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ISSN
1745-6215
E-ISSN
1745-6215
DOI
10.1186/s13063-021-05266-w
