An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, bio...
An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
About this item
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Author / Creator
Evans, Brian C. , Fletcher, R. Brock , Kilchrist, Kameron V. , Dailing, Eric A. , Mukalel, Alvin J. , Colazo, Juan M. , Oliver, Matthew , Cheung-Flynn, Joyce , Brophy, Colleen M. , Tierney, John W. , Isenberg, Jeffrey S. , Hankenson, Kurt D. , Ghimire, Kedar , Lander, Cynthia , Gersbach, Charles A. and Duvall, Craig L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small molecules. Most peptides and biologics are fused with cationic uptake moieties or formulated into nanoparticles to facilitate delivery, but these systems typically lack potency due to low uptake and/or entrapment and degradation...
Alternative Titles
Full title
An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_527a6ef95d124979b5fd95a610cb9fb1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_527a6ef95d124979b5fd95a610cb9fb1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12906-y
