PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia
PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia
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Germany: John Wiley & Sons, Inc
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Language
English
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Publisher
Germany: John Wiley & Sons, Inc
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Background
Chemotherapy induces a cachectic‐like phenotype, accompanied by skeletal muscle wasting, weakness and mitochondrial dysfunction. Peroxisome proliferator‐activated receptor‐gamma coactivator‐1 alpha (PGC1α), a regulator of mitochondrial biogenesis, is often reduced in cachectic skeletal muscle. Overexpression of PGC1α has yielded mixed...
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Full title
PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia
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TN_cdi_doaj_primary_oai_doaj_org_article_527c4592d80b4722ad3b7a66e827a803
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_527c4592d80b4722ad3b7a66e827a803
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ISSN
2190-5991
E-ISSN
2190-6009
DOI
10.1002/jcsm.13035
