Roles of Volume-sensitive Cl- Channel on Apoptosis and Drug Resistance in Cancer Cells.
Roles of Volume-sensitive Cl- Channel on Apoptosis and Drug Resistance in Cancer Cells.
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China: Chinese Anti-Cancer Association Chinese Antituberculosis Association
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Language
Chinese
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Publisher
China: Chinese Anti-Cancer Association Chinese Antituberculosis Association
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Contents
肺癌是当今世界上严重威胁人类健康与生命的恶性肿瘤，其发病率和死亡率为男性恶性肿瘤的第一位，女性为第二位。随着我国人 自然增长和人 老龄化进程加剧，肺癌的发病与死亡在相当一段时间内居我国恶性肿瘤的首位。由于诸多因素，肺癌患者到临床就诊时已多属晚期，失去了手术治疗的最佳时间。我国肺癌总的5年生存率仅为10%左右。因此多数肺癌需进行以化疗为主的综合治疗，而在化疗过程中多数患者会出现耐药现象。最新研究[1,2]发现容积敏感性氯离子通道和肿瘤细胞耐药的发生和发展密切相关，通过抑制容积敏感性氯离子通道的活性，能够明显降低肿瘤细胞对化疗药的敏感性，在诱导产生耐药的人表皮癌细胞系KCP-4细胞中，几乎没有容积敏感性氯离子通道的活动，而在恢复容积敏感性氯离子通道的活性之后，人表皮癌细胞系KCP-4细胞再次表现...
Alternative Titles
Full title
Roles of Volume-sensitive Cl- Channel on Apoptosis and Drug Resistance in Cancer Cells.
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TN_cdi_doaj_primary_oai_doaj_org_article_52891f0cd2be444fbe73107ab54b2e7d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_52891f0cd2be444fbe73107ab54b2e7d
Other Identifiers
ISSN
1009-3419
E-ISSN
1999-6187
DOI
10.3779/j.issn.1009-3419.2009.11.16
