The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in...
The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Serum monoclonal immunoglobulin (Ig) is the main diagnostic factor for patients with multiple myeloma (MM), however its prognostic potential remains unclear. On a large MM patient cohort (n = 4146), we observe no correlation between serum Ig levels and patient survival, while amount of intracellular Ig has a strong predictive effect. Focused CRISPR...
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Full title
The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
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TN_cdi_doaj_primary_oai_doaj_org_article_52b4b9da740040788e35b26372435d0d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_52b4b9da740040788e35b26372435d0d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34654-2
