Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthi...
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
About this item
Full title
Author / Creator
Barekatain, Yasaman , Ackroyd, Jeffrey J. , Yan, Victoria C. , Khadka, Sunada , Wang, Lin , Chen, Ko-Chien , Poral, Anton H. , Tran, Theresa , Georgiou, Dimitra K. , Arthur, Kenisha , Lin, Yu-Hsi , Satani, Nikunj , Ballato, Elliot S. , Behr, Eliot I. , deCarvalho, Ana C. , Verhaak, Roel G. W. , de Groot, John , Huse, Jason T. , Asara, John M. , Kalluri, Raghu and Muller, Florian L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Homozygous deletion of methylthioadenosine phosphorylase (
MTAP
) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous
MTAP
-deleted cell lines in culture show elevation of MTAP’s substrate metabolite, methylthioadenosine (MTA). High levels of MTA inhibit protein arginine methyltransferase 5 (PRM...
Alternative Titles
Full title
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
Authors, Artists and Contributors
Author / Creator
Ackroyd, Jeffrey J.
Yan, Victoria C.
Khadka, Sunada
Wang, Lin
Chen, Ko-Chien
Poral, Anton H.
Tran, Theresa
Georgiou, Dimitra K.
Arthur, Kenisha
Lin, Yu-Hsi
Satani, Nikunj
Ballato, Elliot S.
Behr, Eliot I.
deCarvalho, Ana C.
Verhaak, Roel G. W.
de Groot, John
Huse, Jason T.
Asara, John M.
Kalluri, Raghu
Muller, Florian L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_52cd1479712f4a068ae698d7e4c9858e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_52cd1479712f4a068ae698d7e4c9858e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24240-3
