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Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis thro...

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Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis thro...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_52dc0cfc7d72406b8dc456fc310de27a

Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation

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Full title

Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation

Author / Creator

Ring, Nadja Anneliese Ruth , Volpe, Maria Concetta , Stepišnik, Tomaž , Mamolo, Maria Grazia , Panov, Panče , Kocev, Dragi , Vodret, Simone , Fortuna, Sara , Calabretti, Antonella , Rehman, Michael , Colliva, Andrea , Marchesan, Pietro , Camparini, Luca , Marcuzzo, Thomas , Bussani, Rossana , Scarabellotto, Sara , Confalonieri, Marco , Pham, Tho X. , Ligresti, Giovanni , Caporarello, Nunzia , Loffredo, Francesco S. , Zampieri, Daniele , Džeroski, Sašo and Zacchigna, Serena

Publisher

London: Nature Publishing Group UK

Journal title

Cell death & disease, 2021-12, Vol.13 (1), p.2-12, Article 2

Language

English

Formats

Articles

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

Subjects and topics

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Scope and Contents

Contents

Summary
Therapies halting the progression of fibrosis are ineffective and limited. Activated myofibroblasts are emerging as important targets in the progression of fibrotic diseases. Previously, we performed a high-throughput screen on lung fibroblasts and subsequently demonstrated that the inhibition of myofibroblast activation is able to preve...

Alternative Titles

Full title

Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation

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Author / Creator

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Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_52dc0cfc7d72406b8dc456fc310de27a

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_52dc0cfc7d72406b8dc456fc310de27a

Other Identifiers

ISSN

2041-4889

E-ISSN

2041-4889

DOI

10.1038/s41419-021-04439-4

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