hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’...
hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The tyrosine kinase receptor encoded by the MET oncogene is a major player in cancer. When MET is responsible for the onset and progression of the transformed phenotype (MET-addicted cancers), an efficient block of its oncogenic activation results in potent tumor growth inhibition.
Here we describe a molecular engineered MET antibody (hOA-DN30)...
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Full title
hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5300d21aef514f059e95f9114917da72
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5300d21aef514f059e95f9114917da72
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ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-022-02320-6
