Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy respon...
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
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Author / Creator
SYSCID Consortium , Mishra, Neha , Aden, Konrad , Blase, Johanna I. , Baran, Nathan , Bordoni, Dora , Tran, Florian , Conrad, Claudio , Avalos, Diana , Jaeckel, Charlot , Scherer, Michael , Sørensen, Signe B. , Overgaard, Silja H. , Schulte, Berenice , Nikolaus, Susanna , Rey, Guillaume , Gasparoni, Gilles , Lyons, Paul A. , Schultze, Joachim L. , Walter, Jörn , Andersen, Vibeke , Banos, Aggelos , Bertsias, George , Beyer, Marc , Boumpas, Dimitrios , Finckh, Axel , Franke, Andre , Georges, Michel , Gu, Wei , Häsler, Robert , Jawhara, Mohamad , Kenyon, Amy , Kratsch, Christina , Krause, Roland , Lauc, Gordan , Mangino, Massimo , Natoli, Gioacchino , Ostaszewski, Marek , Pezer, Marija , Raes, Jeroen , Rahmouni, Souad , Ramos-Pamplona, Marilou , Reiz, Benedikt , Rosati, Elisa , Sanoudou, Despina , Satagopam, Venkata , Schneider, Reinhard , Schulte-Schrepping, Jonas , Sidiropoulos, Prodromos , Smith, Kenneth G. C. , Spector, Timothy , Vandeputte, Doris , Vieira-Silva, Sara , Vojta, Aleksandar , Warnat-Herresthal, Stefanie , Zoldoš, Vlatka , Dermitzakis, Emmanouil T. , Schreiber, Stefan and Rosenstiel, Philip
Publisher
London: BioMed Central Ltd
Journal title
Language
English
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Publisher
London: BioMed Central Ltd
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Contents
Background and aims Treatment with tumor necrosis factor [alpha] (TNF[alpha]) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated the dynamics of gene expression and DNA methylation in blood samples of IBD patients treated with the TNF anta...
Alternative Titles
Full title
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
Authors, Artists and Contributors
Author / Creator
Mishra, Neha
Aden, Konrad
Blase, Johanna I.
Baran, Nathan
Bordoni, Dora
Tran, Florian
Conrad, Claudio
Avalos, Diana
Jaeckel, Charlot
Scherer, Michael
Sørensen, Signe B.
Overgaard, Silja H.
Schulte, Berenice
Nikolaus, Susanna
Rey, Guillaume
Gasparoni, Gilles
Lyons, Paul A.
Schultze, Joachim L.
Walter, Jörn
Andersen, Vibeke
Banos, Aggelos
Bertsias, George
Beyer, Marc
Boumpas, Dimitrios
Finckh, Axel
Franke, Andre
Georges, Michel
Gu, Wei
Häsler, Robert
Jawhara, Mohamad
Kenyon, Amy
Kratsch, Christina
Krause, Roland
Lauc, Gordan
Mangino, Massimo
Natoli, Gioacchino
Ostaszewski, Marek
Pezer, Marija
Raes, Jeroen
Rahmouni, Souad
Ramos-Pamplona, Marilou
Reiz, Benedikt
Rosati, Elisa
Sanoudou, Despina
Satagopam, Venkata
Schneider, Reinhard
Schulte-Schrepping, Jonas
Sidiropoulos, Prodromos
Smith, Kenneth G. C.
Spector, Timothy
Vandeputte, Doris
Vieira-Silva, Sara
Vojta, Aleksandar
Warnat-Herresthal, Stefanie
Zoldoš, Vlatka
Dermitzakis, Emmanouil T.
Schreiber, Stefan
Rosenstiel, Philip
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_533221e6756c4c1d84dece9aba5649b6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_533221e6756c4c1d84dece9aba5649b6
Other Identifiers
ISSN
1756-994X
E-ISSN
1756-994X
DOI
10.1186/s13073-022-01112-z
