Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hyper...
Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant cell lines were determined using the MTT assay. Effects of Shikonin derivatives on BCRP, MDR1 and MRP transcript and protein levels were relatively measured. Finally, accumulation and efflux...
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Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells
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TN_cdi_doaj_primary_oai_doaj_org_article_534d720ee60745529e4a16bb37e6cfbc
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_534d720ee60745529e4a16bb37e6cfbc
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-21710-5
