MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction an...
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
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Author / Creator
Clabbers, Max T. B. , Holmes, Susannah , Muusse, Timothy W. , Vajjhala, Parimala R. , Thygesen, Sara J. , Malde, Alpeshkumar K. , Hunter, Dominic J. B. , Croll, Tristan I. , Flueckiger, Leonie , Nanson, Jeffrey D. , Rahaman, Md. Habibur , Aquila, Andrew , Hunter, Mark S. , Liang, Mengning , Yoon, Chun Hong , Zhao, Jingjing , Zatsepin, Nadia A. , Abbey, Brian , Sierecki, Emma , Gambin, Yann , Stacey, Katryn J. , Darmanin, Connie , Kobe, Bostjan , Xu, Hongyi , Ve, Thomas and SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MAL
TIR
) forms filaments in vitro and induces formation of crystalline higher-order assemblies of the MyD88 TIR domain (MyD88
TIR
). These crystals are too small for conventi...
Alternative Titles
Full title
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
Authors, Artists and Contributors
Author / Creator
Holmes, Susannah
Muusse, Timothy W.
Vajjhala, Parimala R.
Thygesen, Sara J.
Malde, Alpeshkumar K.
Hunter, Dominic J. B.
Croll, Tristan I.
Flueckiger, Leonie
Nanson, Jeffrey D.
Rahaman, Md. Habibur
Aquila, Andrew
Hunter, Mark S.
Liang, Mengning
Yoon, Chun Hong
Zhao, Jingjing
Zatsepin, Nadia A.
Abbey, Brian
Sierecki, Emma
Gambin, Yann
Stacey, Katryn J.
Darmanin, Connie
Kobe, Bostjan
Xu, Hongyi
Ve, Thomas
SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5393cc79aa8d46d7b03a93a616d4e3b9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5393cc79aa8d46d7b03a93a616d4e3b9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22590-6
