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MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction an...

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction an...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5393cc79aa8d46d7b03a93a616d4e3b9

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

About this item

Full title

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2021-05, Vol.12 (1), p.2578-14, Article 2578

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MAL
TIR
) forms filaments in vitro and induces formation of crystalline higher-order assemblies of the MyD88 TIR domain (MyD88
TIR
). These crystals are too small for conventi...

Alternative Titles

Full title

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_5393cc79aa8d46d7b03a93a616d4e3b9

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5393cc79aa8d46d7b03a93a616d4e3b9

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-021-22590-6