Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer
Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer
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Moyano‐Galceran, Lidia , Pietilä, Elina A , Turunen, S Pauliina , Corvigno, Sara , Hjerpe, Elisabet , Bulanova, Daria , Joneborg, Ulrika , Alkasalias, Twana , Miki, Yuichiro , Yashiro, Masakazu , Chernenko, Anastasiya , Jukonen, Joonas , Singh, Madhurendra , Dahlstrand, Hanna , Carlson, Joseph W and Lehti, Kaisa
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Metastatic cancers commonly activate adaptive chemotherapy resistance, attributed to both microenvironment‐dependent phenotypic plasticity and genetic characteristics of cancer cells. However, the contribution of chemotherapy itself to the non‐genetic resistance mechanisms was long neglected. Using high‐grade serous ovarian cancer (HGSC) patient ma...
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Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_53a1f3dd95a442a0b1b984d8469f054e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_53a1f3dd95a442a0b1b984d8469f054e
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ISSN
1757-4676,1757-4684
E-ISSN
1757-4684
DOI
10.15252/emmm.201911177
