Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and cl...
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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ABSTRACT
HIV viremia can be controlled by chronic antiretroviral therapy. As a potentially single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) are capable of secreting high antibody titers. Here, we show that, upon immunization of mice, adoptively transferred engineered B cells h...
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Full title
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
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TN_cdi_doaj_primary_oai_doaj_org_article_53cea78635c1437b9150abc735992dd8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_53cea78635c1437b9150abc735992dd8
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19649-1
