Antimalarial activity of primaquine operates via a two-step biochemical relay
Antimalarial activity of primaquine operates via a two-step biochemical relay
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Primaquine (PQ) is an essential antimalarial drug but despite being developed over 70 years ago, its mode of action is unclear. Here, we demonstrate that hydroxylated-PQ metabolites (OH-PQm) are responsible for efficacy against liver and sexual transmission stages of
Plasmodium falciparum
. The antimalarial activity of PQ against liver stages...
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Full title
Antimalarial activity of primaquine operates via a two-step biochemical relay
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TN_cdi_doaj_primary_oai_doaj_org_article_53df786506df4fffaf54431621d57eba
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_53df786506df4fffaf54431621d57eba
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11239-0
