Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
About this item
Full title
Author / Creator
Santos, Maria C. Ferreira dos , Anderson, Cole P. , Neschen, Susanne , Zumbrennen-Bullough, Kimberly B. , Romney, Steven J. , Kahle-Stephan, Melanie , Rathkolb, Birgit , Gailus-Durner, Valerie , Fuchs, Helmut , Wolf, Eckhard , Rozman, Jan , de Angelis, Martin Hrabe , Cai, Weiling Maggie , Rajan, Malini , Hu, Jennifer , Dedon, Peter C. and Leibold, Elizabeth A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Regulation of cellular iron homeostasis is crucial as both iron excess and deficiency cause hematological and neurodegenerative diseases. Here we show that mice lacking iron-regulatory protein 2 (Irp2), a regulator of cellular iron homeostasis, develop diabetes. Irp2 post-transcriptionally regulates the iron-uptake protein transferrin receptor 1 (T...
Alternative Titles
Full title
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
Authors, Artists and Contributors
Author / Creator
Anderson, Cole P.
Neschen, Susanne
Zumbrennen-Bullough, Kimberly B.
Romney, Steven J.
Kahle-Stephan, Melanie
Rathkolb, Birgit
Gailus-Durner, Valerie
Fuchs, Helmut
Wolf, Eckhard
Rozman, Jan
de Angelis, Martin Hrabe
Cai, Weiling Maggie
Rajan, Malini
Hu, Jennifer
Dedon, Peter C.
Leibold, Elizabeth A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_53f26f3f35f1461a9fc51b7c51673141
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_53f26f3f35f1461a9fc51b7c51673141
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-14004-5
