Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
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Author / Creator
Gao, Juan , Bao, Yun , Ge, Shushu , Sun, Peisen , Sun, Jiaojiao , Liu, Jianmin , Chen, Feng , Han, Li , Cao, Zhongyuan , Qin, Jun , White, Gilbert C. , Xu, Zhen and Ma, Yan-Qing
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits.
Here we employed biochemical approaches and cellular analyses to evaluate the function and molecular mechanism of the sharpin-kindlin-1 comp...
Alternative Titles
Full title
Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_548b2a1b17874aa48c5851a2d0730e9d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_548b2a1b17874aa48c5851a2d0730e9d
Other Identifiers
ISSN
1478-811X
E-ISSN
1478-811X
DOI
10.1186/s12964-019-0407-6
