19 Preclinical CD3-based mouse models for evaluation of bi-specific T-cell engager antibodies
19 Preclinical CD3-based mouse models for evaluation of bi-specific T-cell engager antibodies
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London: BMJ Publishing Group Ltd
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English
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London: BMJ Publishing Group Ltd
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BackgroundThe T-cell receptor (TCR)- CD3 complex plays a critical role in mediating T-cell activation and cellular immune response. Key signaling subunits of the CD3 co-receptor include CD3ε, CD3δ, and CD3γ. In recent years, an attractive therapeutic approach for cancer treatment uses bispecific antibodies that target human CD3 and a tumor-associat...
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19 Preclinical CD3-based mouse models for evaluation of bi-specific T-cell engager antibodies
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TN_cdi_doaj_primary_oai_doaj_org_article_54af7137e1b34521adc6c08c73b5d335
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_54af7137e1b34521adc6c08c73b5d335
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E-ISSN
2051-1426
DOI
10.1136/jitc-2023-SITC2023.0019
