MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and maintenance of cancer stem cells. However, how other oncogenic pathways converge on Wnt signalling to modulate stem cell homeostasis in CRC currently remains poorly understood. Using large-scale compound screens in CRC, we identify MEK1/2 inhibitors as potent act...
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Full title
MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_54b4ea38523f4011a819f580a23a3c55
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_54b4ea38523f4011a819f580a23a3c55
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09898-0
