IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation
IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation
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Author / Creator
Fan, Hong , Yang, Jialei , Zhang, Kun , Xing, Junling , Guo, Baolin , Mao, Honghui , Wang, Wenting , Hu, Yingzhou , Lin, Wei , Huang, Ying , Ding, Jian , Yu, Caiyong , Fu, Fanfan , Sun, Li , Wu, Jing , Zhao, Youyi , Deng, Wenbin , Zhou, Chengji , Qiu, Mengsheng , Wu, Shengxi , Ding, Yu-Qiang and Wang, Yazhou
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Reactive astrogliosis usually bears some properties of neural progenitors. How injury triggers astrocyte dedifferentiation remains largely unclear. Here, we report that ischemia induces rapid up-regulation of Wnt2 protein in apoptotic neurons and activation of canonical Wnt signaling in reactive astrocytes in mice, primates and human. Local deliver...
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Full title
IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation
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TN_cdi_doaj_primary_oai_doaj_org_article_5551ee1e4cd24382b142c66bf6f4be8a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5551ee1e4cd24382b142c66bf6f4be8a
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ISSN
2057-3995
E-ISSN
2057-3995
DOI
10.1038/s41536-022-00248-1
