Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies
Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies
About this item
Full title
Author / Creator
Gu, Danling , Tang, Hanning , Wu, Jiazhu , Li, Jianyong and Miao, Yi
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
B cell receptor (BCR) signaling is involved in the pathogenesis of B cell malignancies. Activation of BCR signaling promotes the survival and proliferation of malignant B cells. Bruton tyrosine kinase (BTK) is a key component of BCR signaling, establishing BTK as an important therapeutic target. Several covalent BTK inhibitors have shown remarkable...
Alternative Titles
Full title
Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_557fae3ccc224792b23426e77330dc47
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_557fae3ccc224792b23426e77330dc47
Other Identifiers
ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-021-01049-7
