Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein...
Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells
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Author / Creator
Lu, Xuxiu , Geng, Jiajia , Zhang, Jinman , Miao, Jinlai and Liu, Ming
Publisher
Basel: MDPI AG
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Language
English
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Publisher
Basel: MDPI AG
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Contents
BCR-ABL oncoprotein drives the initiation, promotion, and progression of chronic myelogenous leukemia (CML). Tyrosine kinase inhibitors are the first choice for CML therapy, however, BCR-ABL mediated drug resistance limits its clinical application and prognosis. A novel promising therapeutic strategy for CML therapy is to degrade BCR-ABL using smal...
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Full title
Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells
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TN_cdi_doaj_primary_oai_doaj_org_article_5591b9089dde47598393b92331c0df8b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5591b9089dde47598393b92331c0df8b
Other Identifiers
ISSN
2076-3921
E-ISSN
2076-3921
DOI
10.3390/antiox8090402
