PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
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England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various
BRCA
-mutated tumors. PARPi possess both PARP1 inhibition and PARP1 trapping activities. The relative contribution of these two mechanisms toward PARPi-induced innate immune signaling, however, is...
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Full title
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
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TN_cdi_doaj_primary_oai_doaj_org_article_55d1ca092f654661b0db3c56246bce03
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_55d1ca092f654661b0db3c56246bce03
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.60637
