Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity...
Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension
About this item
Full title
Author / Creator
Berger, Justin H. , Shi, Yuji , Matsuura, Timothy R. , Batmanov, Kirill , Chen, Xian , Tam, Kelly , Marshall, Mackenzie , Kue, Richard , Patel, Jiten , Taing, Renee , Callaway, Russell , Griffin, Joanna , Kovacs, Attila , Hirenallur-Shanthappa, Dinesh , Miller, Russell , Zhang, Bei B. , Flach, Rachel J. Roth and Kelly, Daniel P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Heart failure with preserved ejection fraction (HFpEF) is increasingly common but its pathogenesis is poorly understood. The ability to assess genetic and pharmacologic interventions is hampered by the lack of robust preclinical mouse models of HFpEF. We developed a novel “two-hit” model, which combines obesity and insulin resistance with chronic p...
Alternative Titles
Full title
Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_55f8f7dfdf724c7d9cda3fddaa0efab9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_55f8f7dfdf724c7d9cda3fddaa0efab9
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-84515-9
