Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Although the process of autophagy has been extensively studied, the mechanisms that regulate it remain insufficiently understood. To identify novel autophagy regulators, we performed a whole-genome CRISPR/Cas9 knockout screen in H4 human neuroglioma cells expressing endogenous LC3B tagged with a tandem of GFP and mCherry. Using this methodology, we...
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Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
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TN_cdi_doaj_primary_oai_doaj_org_article_5613fd83227d40cf9b03e8ccce1b5ef8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5613fd83227d40cf9b03e8ccce1b5ef8
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.50034
