Large parental differences in chromatin organization in pancreatic beta cell line explaining diabete...
Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
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Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Previous GWAS studies identified non-coding loci with parent-of-origin-specific effects on Type 2 diabetes susceptibility. Here we report the molecular basis for one such locus near the
KRTAP5-6
gene on chromosome 11. We determine the pattern of long-range contacts between an enhancer in this locus and the human
INS
promoter 460 kb away...
Alternative Titles
Full title
Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
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TN_cdi_doaj_primary_oai_doaj_org_article_56388fac1a3b48b0b366720ad06fb8ac
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_56388fac1a3b48b0b366720ad06fb8ac
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24635-2
