Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischem...
Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury
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Author / Creator
Zhao, Jing , Wang, Guorong , Han, Kaitao , Wang, Yang , Wang, Lin , Gao, Jinxia , Zhao, Sen , Wang, Gang , Chen, Shengyang , Luo, An , Wu, Jianlin and Wang, Guangzhi
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Apoptosis is a critical event in the pathogenesis of lung ischemia/reperfusion (I/R) injury. Sirtuin 3 (SIRT3), an important deacetylase predominantly localized in mitochondria, regulates diverse physiological processes, including apoptosis. However, the detailed mechanisms by which SIRT3 regulates lung I/R injury remain unclear. Many polyphenols s...
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Full title
Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury
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TN_cdi_doaj_primary_oai_doaj_org_article_563b2f3ff893454cb1e762995e8d58e5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_563b2f3ff893454cb1e762995e8d58e5
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-022-05051-w
