mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclero...
mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Previous studies report a cross-talk between the polycystic kidney disease (PKD) and tuberous sclerosis complex (TSC) genes. mTOR signalling is upregulated in PKD and rapamycin slows cyst expansion, whereas renal inactivation of the
Tsc
genes causes cysts. Here we identify a new interplay between the PKD and TSC genes, with important implicat...
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mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex
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TN_cdi_doaj_primary_oai_doaj_org_article_5661208307ac486ca0832b838a77050f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5661208307ac486ca0832b838a77050f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10786
