Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage...
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
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Author / Creator
Kurelac, Ivana , Iommarini, Luisa , Vatrinet, Renaud , Amato, Laura Benedetta , De Luise, Monica , Leone, Giulia , Girolimetti, Giulia , Umesh Ganesh, Nikkitha , Bridgeman, Victoria Louise , Ombrato, Luigi , Columbaro, Marta , Ragazzi, Moira , Gibellini, Lara , Sollazzo, Manuela , Feichtinger, Rene Gunther , Vidali, Silvia , Baldassarre, Maurizio , Foriel, Sarah , Vidone, Michele , Cossarizza, Andrea , Grifoni, Daniela , Kofler, Barbara , Malanchi, Ilaria , Porcelli, Anna Maria and Gasparre, Giuseppe
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Converting carcinomas in benign oncocytomas has been suggested as a potential anti-cancer strategy. One of the oncocytoma hallmarks is the lack of respiratory complex I (CI). Here we use genetic ablation of this enzyme to induce indolence in two cancer types, and show this is reversed by allowing the stabilization of Hypoxia Inducible Factor-1 alph...
Alternative Titles
Full title
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
Authors, Artists and Contributors
Author / Creator
Iommarini, Luisa
Vatrinet, Renaud
Amato, Laura Benedetta
De Luise, Monica
Leone, Giulia
Girolimetti, Giulia
Umesh Ganesh, Nikkitha
Bridgeman, Victoria Louise
Ombrato, Luigi
Columbaro, Marta
Ragazzi, Moira
Gibellini, Lara
Sollazzo, Manuela
Feichtinger, Rene Gunther
Vidali, Silvia
Baldassarre, Maurizio
Foriel, Sarah
Vidone, Michele
Cossarizza, Andrea
Grifoni, Daniela
Kofler, Barbara
Malanchi, Ilaria
Porcelli, Anna Maria
Gasparre, Giuseppe
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5695fa0483614fb297fba6aa895d1974
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5695fa0483614fb297fba6aa895d1974
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08839-1
