Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic s...
Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage
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Author / Creator
Han, Teng-Long , Sha, Hang , Ji, Jun , Li, Yun-Tian , Wu, Deng-Shan , Lin, Hu , Hu, Bin and Jiang, Zhi-Xin
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The anticancer effects of taxanes are attributed to the induction of mitotic arrest through activation of the spindle assembly checkpoint. Cell death following extended mitotic arrest is mediated by the intrinsic apoptosis pathway. Accordingly, factors that influence the robustness of mitotic arrest or disrupt the apoptotic machinery confer drug re...
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Full title
Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage
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TN_cdi_doaj_primary_oai_doaj_org_article_569d1d72d46642f7bde9fd7f54bd17a3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_569d1d72d46642f7bde9fd7f54bd17a3
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-81563-3
