AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
About this item
Full title
Author / Creator
Taniguchi, Hirokazu , Yamada, Tadaaki , Wang, Rong , Tanimura, Keiko , Adachi, Yuta , Nishiyama, Akihiro , Tanimoto, Azusa , Takeuchi, Shinji , Araujo, Luiz H. , Boroni, Mariana , Yoshimura, Akihiro , Shiotsu, Shinsuke , Matsumoto, Isao , Watanabe, Satoshi , Kikuchi, Toshiaki , Miura, Satoru , Tanaka, Hiroshi , Kitazaki, Takeshi , Yamaguchi, Hiroyuki , Mukae, Hiroshi , Uchino, Junji , Uehara, Hisanori , Takayama, Koichi and Yano, Seiji
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A novel EGFR-tyrosine kinase inhibitor (TKI), osimertinib, has marked efficacy in patients with
EGFR
-mutated lung cancer. However, some patients show intrinsic resistance and an insufficient response to osimertinib. This study showed that osimertinib stimulated AXL by inhibiting a negative feedback loop. Activated AXL was associated with EGF...
Alternative Titles
Full title
AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
Authors, Artists and Contributors
Author / Creator
Yamada, Tadaaki
Wang, Rong
Tanimura, Keiko
Adachi, Yuta
Nishiyama, Akihiro
Tanimoto, Azusa
Takeuchi, Shinji
Araujo, Luiz H.
Boroni, Mariana
Yoshimura, Akihiro
Shiotsu, Shinsuke
Matsumoto, Isao
Watanabe, Satoshi
Kikuchi, Toshiaki
Miura, Satoru
Tanaka, Hiroshi
Kitazaki, Takeshi
Yamaguchi, Hiroyuki
Mukae, Hiroshi
Uchino, Junji
Uehara, Hisanori
Takayama, Koichi
Yano, Seiji
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_56fa97cab04d4e0d8784ee4ba0940412
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_56fa97cab04d4e0d8784ee4ba0940412
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-08074-0
