Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and...
Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer
About this item
Full title
Author / Creator
Luszczak, Sabina , Simpson, Benjamin S. , Stopka-Farooqui, Urszula , Sathyadevan, Vignesh Krishna , Echeverria, Lina M. Carmona , Kumar, Christopher , Costa, Helena , Haider, Aiman , Freeman, Alex , Jameson, Charles , Ratynska, Marzena , Ben-Salha, Imen , Sridhar, Ashwin , Shaw, Greg , Kelly, John D. , Pye, Hayley , Gately, Kathy A. , Whitaker, Hayley C. and Heavey, Susan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
PIM and PI3K/mTOR pathways are often dysregulated in prostate cancer, and may lead to decreased survival, increased metastasis and invasion. The pathways are heavily interconnected and act on a variety of common effectors that can lead to the development of resistance to drug inhibitors. Most current treatments exhibit issues with toxicity and resi...
Alternative Titles
Full title
Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer
Authors, Artists and Contributors
Author / Creator
Simpson, Benjamin S.
Stopka-Farooqui, Urszula
Sathyadevan, Vignesh Krishna
Echeverria, Lina M. Carmona
Kumar, Christopher
Costa, Helena
Haider, Aiman
Freeman, Alex
Jameson, Charles
Ratynska, Marzena
Ben-Salha, Imen
Sridhar, Ashwin
Shaw, Greg
Kelly, John D.
Pye, Hayley
Gately, Kathy A.
Whitaker, Hayley C.
Heavey, Susan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5720892a10484524bbddcc6413152966
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5720892a10484524bbddcc6413152966
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-71263-9
