Chemical Modification of Pactamycin Leads to New Compounds with Retained Antimicrobial Activity and...
Chemical Modification of Pactamycin Leads to New Compounds with Retained Antimicrobial Activity and Reduced Toxicity
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Pactamycin (PCT), an antibiotic produced by
, is a five-membered ring aminocyclitol that is active against a variety of Gram-positive and Gram-negative microorganisms, as well as several animal tumor lines in culture and in vivo. Pactamycin targets the small ribosomal subunit and inhibits protein synthesis in bacteria, archaea, and eukaryotes, b...
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Full title
Chemical Modification of Pactamycin Leads to New Compounds with Retained Antimicrobial Activity and Reduced Toxicity
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TN_cdi_doaj_primary_oai_doaj_org_article_572e819f43e249958da866a576b61d73
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_572e819f43e249958da866a576b61d73
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules29174169
