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IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_573c9a6e3c934f97817996bbe29c011b

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

About this item

Full title

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2019-08, Vol.10 (1), p.1-14, Article 3726

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP
3
receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival. It remains unclear whether IP3Rs also have a structural role in contact formation and whether the different IP3R isoforms have redundant functi...

Alternative Titles

Full title

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_573c9a6e3c934f97817996bbe29c011b

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_573c9a6e3c934f97817996bbe29c011b

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-019-11646-3

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