Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mutations in the transcriptional regulator
Mecp2
cause the severe X-linked neurodevelopmental disorder Rett syndrome (RTT). In this study, we investigate genes that function downstream of MeCP2 in cerebral cortex circuitry, and identify upregulation of
Irak1
, a central component of the NF-κB pathway. We show that overexpression of
I...
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Full title
Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
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TN_cdi_doaj_primary_oai_doaj_org_article_573f6b6aaf6a4976a621f82c8007141a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_573f6b6aaf6a4976a621f82c8007141a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10520
