Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairin...
Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination
About this item
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Author / Creator
Zhang, Xin , Xu, Ran , Zhang, Chao , Xu, Yangyang , Han, Mingzhi , Huang, Bin , Chen, Anjing , Qiu, Chen , Thorsen, Frits , Prestegarden, Lars , Bjerkvig, Rolf , Wang, Jian and Li, Xingang
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid tumors. However, current inhibitors do not penetrate the blood-brain-barrier (BBB). Here, we assessed the radiosensitivity effects of the antips...
Alternative Titles
Full title
Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5786791622ef4880b391cdff945d0327
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5786791622ef4880b391cdff945d0327
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-017-0588-z
