Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcript...
Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH receptors traffic retrogradely to the trans-Golgi network (TGN) and activate endo...
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Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription
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TN_cdi_doaj_primary_oai_doaj_org_article_579404a03c0147afacf9210a0eb19e7e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_579404a03c0147afacf9210a0eb19e7e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00357-2
