PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthet...
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1
KO
) reduces muscle mass. PHD1
KO
muscles show impaired mTORC1 activation in response to leucine whereas mTORC1 activation...
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Full title
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
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TN_cdi_doaj_primary_oai_doaj_org_article_57ce964136154da49cd0e8f1b72242c1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_57ce964136154da49cd0e8f1b72242c1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13889-6
