HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic...
HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a
Drosophila
RNA editing enzyme (ADAR) to globally map the mRNA targets of the RBP MSI2 in mammalian adult normal and malignant stem cells. We reveal a unique MUSASHI-2...
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HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_57d9dd401d274463904c8c3f4b95b1ec
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_57d9dd401d274463904c8c3f4b95b1ec
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15814-8
