The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosi...
The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma
About this item
Full title
Author / Creator
Lampis, Silvia , Raieli, Salvatore , Montemurro, Luca , Bartolucci, Damiano , Amadesi, Camilla , Bortolotti, Sonia , Angelucci, Silvia , Scardovi, Anna Lisa , Nieddu, Giammario , Cerisoli, Lucia , Paganelli, Francesca , Valente, Sabrina , Fischer, Matthias , Martelli, Alberto Maria , Pasquinelli, Gianandrea , Pession, Andrea , Hrelia, Patrizia and Tonelli, Roberto
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Neuroblastoma is a deadly childhood cancer, and MYCN-amplified neuroblastoma (MNA-NB) patients have the worst prognoses and are therapy-resistant. While retinoic acid (RA) is beneficial for some neuroblastoma patients, the cause of RA resistance is unknown. Thus, there remains a need for new therapies to treat neuroblastoma. Here we explored the po...
Alternative Titles
Full title
The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma
Authors, Artists and Contributors
Author / Creator
Raieli, Salvatore
Montemurro, Luca
Bartolucci, Damiano
Amadesi, Camilla
Bortolotti, Sonia
Angelucci, Silvia
Scardovi, Anna Lisa
Nieddu, Giammario
Cerisoli, Lucia
Paganelli, Francesca
Valente, Sabrina
Fischer, Matthias
Martelli, Alberto Maria
Pasquinelli, Gianandrea
Pession, Andrea
Hrelia, Patrizia
Tonelli, Roberto
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_57da51d707e148518d41d12e01cff92a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_57da51d707e148518d41d12e01cff92a
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-022-02367-5
