Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The epigenetic mechanisms regulating adipose tissue development and function are poorly understood. In this study, we show that depletion of histone H3K36 methylation by H3.3K36M in preadipocytes inhibits adipogenesis by increasing H3K27me3 to prevent the induction of C/EBPα and other targets of the master adipogenic transcription factor peroxisome...
Alternative Titles
Full title
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_57ecee0efcf14d1483faaa10d2a4a7bd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_57ecee0efcf14d1483faaa10d2a4a7bd
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04127-6
