AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer’s drug disc...
AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer’s drug discovery
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Recent DNA/RNA sequencing and other multi-omics technologies have advanced the understanding of the biology and pathophysiology of AD, yet there is still a lack of disease-modifying treatments for AD. A new approach to integration of the genome, transcriptome, proteome, and human interactome in the drug discovery and development process is essential for this endeavor.
In this study, we developed AlzGPS (Genome-wide Positioning Systems platform for Alzheimer's Drug Discovery, https://alzgps.lerner.ccf.org ), a comprehensive systems biology tool to enable searching, visualizing, and analyzing multi-omics, various types of heterogeneous biological networks, and clinical databases for target identification and development of effective prevention and treatment for AD.
Via AlzGPS: (1) we curated more than 100 AD multi-omics data sets capturing DN...
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AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer’s drug discovery
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TN_cdi_doaj_primary_oai_doaj_org_article_57fab40ecef94245835d5030aa3bd075
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_57fab40ecef94245835d5030aa3bd075
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ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-020-00760-w
