Characterization of G protein coupling mediated by the conserved D1343.49 of DRY motif, M2416.34, an...
Characterization of G protein coupling mediated by the conserved D1343.49 of DRY motif, M2416.34, and F2516.44 residues on human CXCR1
About this item
Full title
Author / Creator
Publisher
Amsterdam: Elsevier B.V
Journal title
Language
English
Formats
Publication information
Publisher
Amsterdam: Elsevier B.V
Subjects
More information
Scope and Contents
Contents
•Mutations in the DRY motif of CXCR1 abolish ligand binding and receptor activation.•Point mutations between TM6 and i3 loop result in constitutive activity of CXCR1.•Constitutive activity of mutant CXCR1 occurs via Gα15 signaling activation.•The highly conserved DRY motifs have distinct roles in CXCR1 and CXCR2.
CXCR1, a receptor for interleuki...
Alternative Titles
Full title
Characterization of G protein coupling mediated by the conserved D1343.49 of DRY motif, M2416.34, and F2516.44 residues on human CXCR1
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_582aedfad6e64137909f4dea1c223748
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_582aedfad6e64137909f4dea1c223748
Other Identifiers
ISSN
2211-5463
E-ISSN
2211-5463
DOI
10.1016/j.fob.2015.03.001
