The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast...
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
About this item
Full title
Author / Creator
Fanning, Sean W , Jeselsohn, Rinath , Dharmarajan, Venkatasubramanian , Mayne, Christopher G , Karimi, Mostafa , Buchwalter, Gilles , Houtman, René , Toy, Weiyi , Fowler, Colin E , Han, Ross , Lainé, Muriel , Carlson, Kathryn E , Martin, Teresa A , Nowak, Jason , Nwachukwu, Jerome C , Hosfield, David J , Chandarlapaty, Sarat , Tajkhorshid, Emad , Nettles, Kendall W , Griffin, Patrick R , Shen, Yang , Katzenellenbogen, John A , Brown, Myles and Greene, Geoffrey L
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Sciences Publications Ltd
Subjects
More information
Scope and Contents
Contents
Acquired resistance to endocrine therapy remains a significant clinical burden for breast cancer patients. Somatic mutations in the
(estrogen receptor alpha (ERα)) gene ligand-binding domain (LBD) represent a recognized mechanism of acquired resistance. Antiestrogens with improved efficacy versus tamoxifen might overcome the resistant phenotype...
Alternative Titles
Full title
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
Authors, Artists and Contributors
Author / Creator
Jeselsohn, Rinath
Dharmarajan, Venkatasubramanian
Mayne, Christopher G
Karimi, Mostafa
Buchwalter, Gilles
Houtman, René
Toy, Weiyi
Fowler, Colin E
Han, Ross
Lainé, Muriel
Carlson, Kathryn E
Martin, Teresa A
Nowak, Jason
Nwachukwu, Jerome C
Hosfield, David J
Chandarlapaty, Sarat
Tajkhorshid, Emad
Nettles, Kendall W
Griffin, Patrick R
Shen, Yang
Katzenellenbogen, John A
Brown, Myles
Greene, Geoffrey L
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_582b84ec644248bbb6fb9af5a9be5532
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_582b84ec644248bbb6fb9af5a9be5532
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.37161
