Targeting tumor-infiltrating CCR8+ regulatory T cells induces antitumor immunity through functional...
Targeting tumor-infiltrating CCR8+ regulatory T cells induces antitumor immunity through functional restoration of CD4+ Tconvs and CD8+ T cells in colorectal cancer
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Author / Creator
Chen, Qian , Shen, Meiying , Yan, Min , Han, Xiaojian , Mu, Song , Li, Ya , Li, Luo , Wang, Yingming , Li, Shenglong , Li, Tingting , Wang, Yingying , Wang, Wang , Wei, Zhengqiang , Hu, Chao and Jin, Aishun
Publisher
London: BioMed Central Ltd
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Language
English
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Publisher
London: BioMed Central Ltd
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Contents
Background Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression mediated by CCR8.sup.+ Tregs observed in breast and lung malignancies suggest for their functional significance in cancer therapy. To date, detailed characterization of tumor-inf...
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Full title
Targeting tumor-infiltrating CCR8+ regulatory T cells induces antitumor immunity through functional restoration of CD4+ Tconvs and CD8+ T cells in colorectal cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_5844da9c306e40a196f6d141ff44bb5f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5844da9c306e40a196f6d141ff44bb5f
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ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/s12967-024-05518-8
